Leukemic Reticuloendotheliosis

Leukemic reticuloendotheliosis (hairy cell leukemia).

Leukopheresis therapy of leukemic reticuloendotheliosis (hairy cell leukemia).

Intensive leukopheresis has been valuable in the short-term palliation of chronic lymphocytic and granulocytic leukemias. A 47-yr-old man with refractory leukemic reticuloendotheliosis (hairy cell leukemia) manifested by anemia, thrombocytopenia, elevated peripheral leukemia cell counts, generalized lymph node enlargement, and leukemic infiltrative skin disease was treated with serial leukopher...

Biochemical, morphological, and immunological observations of leukemic reticuloendotheliosis.

This study reports the biochemical, immunological, and morphological characteristics of the abnormal mononuclear cells from four patients with leukemic reticuloendotheliosis. Two patients had a homogeneous population of mononuclear cells with elevated thymidine incorporation, normal uridine incorporation, suboptimal or delayed response to phytohemagglutinin and a characteristic ultrastructure. ...

The effectiveness of rubidazone in hairy cell leukemia (leukemic reticuloendotheliosis).

Two patients with hairy cell leukemia treated with the anthracycline antibiotic rubidazone are presented. One achieved a complete remission and the other a good partial hematologic and bone marrow remission. Neither has relapsed (at 20 and 13 mo, respectively), and neither has been retreated. Intensive supportive measures were required during the prolonged myelosuppression that followed treatme...

Treatment of hairy cell leukemia (leukemic reticuloendotheliosis) II. Chlorambucil therapy in postsplenectomy patients with progressive disease.

Four postsplenectomy patients with progressive hairy cell leukemia were treated with daily low doses of an alkylating agent (chlorambucil, 4 mg). An objective response, measured by improvement in blood counts in four patients as well as decreased bone marrow involvement on core biopsy in three patients, could be documented within 6 mo. It is important to identify the postsplenectomy patient wit...